AG Lautenschläger


ORCID: 0000-0002-3596-1915

ResearcherID: CEV-0330-2022

Campus D2 2, D-66123 Saarbrücken

s8cabalt(at)stud.uni-saarland.de

+49 681 9300 366


Research Topics

Cell Biology

Actin

Experimental Physics

Biophysics

Micropatterning

Migration

Confinement

M.Sc. Carsten Baltes

Ph.D. Student

Carsten Baltes is a PhD student in the group of Prof. Dr. Franziska Lautenschläger ("cytoskeletal fibers"). He started his PhD project in April 2021, which deals with the role of cytoskeletal proteins, especially actin, in migrating cells. He is using various compounds such as miuraenamide A, latrunculin A and blebbistatin to alter the architecture and dynamics of the actin network in living cells. To further analyze the effects of these changes, he uses several techniques: Deep-UV micropatterning, PRIMO micropatterning, PDMS microfrabrications, fluorescence recovery after photobleaching (FRAP), pattern-based contractility screening (PaCS), and more. His goal is to understand how changes in the actin network can ultimately be used to find new targets for pharmaceutical compounds that could help fight diseases such as chronic bowel inflammation or cancer.

Links

CV
Research Gate

Publications

  • Evans, C.A.; Kim, H.R.; Macfarlane, S.C.; Nowicki, P.I.A.; Baltes, C.; Xu, L.; Widengren, J.; Lautenschläger, F.; Corfe, B.M.; Gad, A.K.B. Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes in the Vimentin Interactome. Int. J. Mol. Sci. 2022, 23, 1961. https://doi.org/10.3390/ijms23041961
  • Baltes C, Thalla DG, Kazmaier U, Lautenschläger F. Actin stabilization in cell migration. Front Cell Dev Biol. 2022 Aug 11;10:931880. doi: 10.3389/fcell.2022.931880. PMID: 36035985; PMCID: PMC9403840.
  • Ullrich KA, Derdau J, Baltes C, et al. IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells; Gut 2023;72:2081-2094.
  • A. A. Fischer, H. B. Robertson, D. Kong, M. M. Grimm, J. Grether, J. Groth, C. Baltes, M. Fliegauf, F. Lautenschläger, B. Grimbacher, H. Ye, V. Helms, W. Weber, Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice. Small 2024, 20, 2311834. https://doi.org/10.1002/smll.202311834