Contact Information

Vita

I am a dedicated and enthusiastic biological scientist specializing in T-cells. My research journey started focused on Interleukin-2 and rationally designed mutants to influence the T-effector/T-regulatory balance with a positive impact on cancer treatment. I then worked on optimizing T-cell expansion conditions, developing a patented method for fine-tuning cell differentiation before transfer therapies. More recently, I started to explore the pivotal role of the T-cell cytoskeleton in migration and infiltration. By targeting cytoskeleton components with tailored drugs, I have significantly enhanced T-cell searching efficiency. Because limited T-cell infiltration in tumors is a major hurdle in cancer immunotherapy, I aim to synergize with existing approaches and pioneer cytoskeleton-based strategies for adoptive transfer therapies. With over a decade of research in interdisciplinary teams, my unique expertise allows me to contribute to advancing cell-based immunotherapies.

Publications

Transcriptional reprogramming by IL-2 variant generates metabolically active stem-like T cells (Preprint) / 2023 link

PIEZO1-mediated mechanosensing governs NK cell killing efficiency in 3D (Preprint) / 2023 link

METHOD FOR THE EXPANSION AND DIFFERENTIATION OF T LYMPHOCYTES AND NK CELLS IN ADOPTIVE TRANSFER THERAPIES / 2022 / ZA. Patent No.202107758 link

The role of actin and myosin II in the cell cortex of adhered and suspended cells (Preprint) / 2021 link

Differential Effects of IL2Rα and IL15Rα over the Stability of the Common Beta-Gamma Signaling Subunits of the IL2 and IL15 Receptors / 2021 link

Characterization of immune cell migration using microfabrication / 2021 link